A comparison of the integration of Risk management Principles in Product Development Approaches

The management and reduction of risk is a central part of product development processes. This paper analyses the extent to which four common product development approaches address risks (waterfall model, stage gate model, design for six sigma, and lean product development). They are analyzed along the four principles of risk-driven design: 1. Identifying and quantifying risks; 2. Making risk-based decisions; 3. Reducing risks; and 4. Creating resilient PD systems. The analysis shows that the existing PD processes only partially address the four principles of risk-driven design and that they have their specific strengths and weaknesses. The paper concludes with a discussion of preliminary empirical findings through interviews and case studies on how to better integrate risk management principles into product development.Massachusetts Institute of Technology. Lean Advancement InitiativeCenter for Clean Water and Clean Energy at MIT and KFUP

Risk Management in Product Design: Current State, Conceptual Model and Future Research

Risk management is an important element of product design. It helps to minimize the project- and product-related risks such as project budget and schedule overrun, or missing product cost and quality targets. Risk management is especially important for complex, international product design projects that involve a high degree of novel technology. This paper reviews the literature on risk management in product design. It examines the newly released international standard ISO 31000 “Risk management — Principles and guidelines” and explores its applicability to product design. The new standard consists of the seven process steps communication and consultation; establishing the context; risk identification; risk analysis; risk evaluation; risk treatment; and monitoring and review. A literature review reveals, among other findings, that the general ISO 31000 process model seems applicable to risk management in product design; the literature addresses different process elements to varying degrees, but none fully according to ISO recommendations; and that the integration of product design risk management with risk management of other disciplines, or between project and portfolio level in product design, is not well developed

Characteristics of successful risk management in product design

The paper reports results of one of the largest empirical studies to-date on the impact of design risk management practices on product design success. Through a survey of 224 practices, 38 (in 7 categories) where found to be statistically significant for at least 3 out of 4 performance metrics. The categories are: 1. Organizational Design Experience; 2. Risk Management Personnel and Resources; 3. Tailoring and Integration of Risk Management Process; 4. Risk-Based Decision Making; 5. Specific Mitigation Actions; 6. Monitoring and Review; and 7. Other ISO Risk Management Principles.King Fahd University of Petroleum and Minerals (Center for Clean Water and Clean Energy at MIT and KFUPM (R11-DMN-09))Massachusetts Institute of Technology. Lean Advancement Initiativ

Text Enhancement in Projected Imagery

There is great interest in improving the visual quality of projectedimagery. In particular, for image enhancement, we would assertthat text and non-text regions should be enhanced differently inseeking to maximize perceived quality, since the spatial and statis-tical characteristics of text and non-text images are quite distinct.In this paper, we present a text enhancement scheme based on anovel local dynamic range statistical thresholding. Given an inputimage, text-like regions are obtained on the basis of computing thelocal statistics of regions having a high dynamic range, allowing apixel-wise classification into text-like or background classes. Theactual enhancement is obtained via class-dependent Wiener filter-ing, with text-like regions sharpened more than the background.Experimental results on four challenging images show that the pro- posed scheme offers a better visual quality than projection with- out enhancement as well as a recent state-of-the-art enhancementmethod

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

A first update on mapping the human genetic architecture of COVID-19

peer reviewe